ICH Trial Update

This course presents updates on the rationale, recruitment and preliminary data of the MISTIE, ENRICH and penumbra trials for intracerebral hemorrhage.

Registration Fee

AANS MembersFree

CME Accreditation

The AANS designates this activity for a maximum of 1.5 AMA PRA Category 1 Credits.

Learning Objectives

After completing this educational activity, participants should be able to:

  • Discuss the rationale for the new set of trials following the results of STICHI and II.
  • Review the differences in techniques between the different trials.
  • Review the inclusion criteria of each trial and how they might differ.



Gustavo Pradilla, MD, FAANS



Adam S. Arthur, MD, MPH, FAANS

Robert F. James, MD, FAANS

Alex Michael, MD

 This educational activity was recorded at the 2019 AANS Annual Scientific Meeting.

Disclosure Information

The AANS controls the content and production of this CME activity and attempts to ensure the presentation of balanced, objective information. In accordance with the Standards for Commercial Support established by the Accreditation Council for Continuing Medical Education (ACCME), speakers, paper presenters/authors and staff (and the significant others of those mentioned) are asked to disclose any relationship they or their co-authors have with commercial interests, which may be related to the content of their lecture.

The ACCME defines “relevant financial relationships” as financial relationships in any amount occurring within the past 12 months that create a conflict of interest. Relationship refers to receipt of royalties, consultantship, funding by research grant, receiving honoraria for education service elsewhere or any other relationship to a commercial interest that provides sufficient reason for disclosure.

It is the policy of the AANS that all individuals in a position to affect the content of a CME activity disclose relationships that they or their spouse/partner have with commercial entities. Further, should any such relationship be determined to be in possible conflict of interest as it relates to the individual’s proposed role in the CME activity, such conflicts of interest will be resolved prior to confirmation of the individual’s participation.

All potential conflicts of interest have been reviewed by an effective peer review committee to ensure the content is valid and aligned with the interest of the activity audience.

Speakers, paper presenters/authors and staff (and the significant others of those mentioned) who have disclosed a relationship with commercial interests whose products may be relevant to their presentation are listed below.

Gustavo Pradilla, MDNICO Corporation, Synaptive MedicalGrants/Research Support
Adam S. Arthur, MD, MPH,Terumo-Microvention,Medtronic, Stryker, Johnson and Johnson, Siemens Medical Systems, Cerebrotech, PenumbraConsultant Fees, Consultant FeesGrants/Research Support,Consultant Fees, Consultant Fees,Consultant FeesGrants/Research Support, Consultant FeesGrant - Industry Research Support, Stock Shareholder
Robert F. James, MD, FAANSRemedy Pharmaceuticals, Inc., Microvention, Inc.,Penumbra, Inc., Medtronic NeurovascularStock Shareholder,Grants/Research Support,Grants/Research Support,Grants/Research Support


The opinions expressed in this educational activity are those of the author and do not necessarily represent the views of the grant provider or the AANS. This educational activity does not endorse one particular type of instrumentation, nor is it intended to dictate an exclusive course of management. It presents one of numerous recognized methods of clinical practice for consideration by physicians for incorporation into their practices. Variations of practice taking into account the needs of the individual patient, resources and limitations unique to the institution or type of practice may be appropriate. Disclosure about patient confidentiality, standards of care or course of management does not imply endorsement or disapproval of products.

Please Note: It is recognized that the use of non-FDA approved devices is described in some of the published material, but these techniques are often the standard of care and may be of value to the patients served.

Accreditation Designation

The AANS is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The AANS designates this internet enduring material activity for a maximum of  1.5 AMA PRA Category 1 CreditsTM.

Physicians should claim only credit commensurate with the extent of their participation in the activity. 

Term of approval is for three years, beginning from 04/6/2020 until 04/6/2023.

© 2019 American Association of Neurological Surgeons


Spontaneous Intracerebral Hemorrhage (ICH): MISTIE III Results and Future Directions
Open to view video.
Open to view video. Robert F. James, MD, FAANS
The MIND Trial
Open to view video.
Open to view video. Adam S. Arthur, MD, MPH, FAANS, FACS
Port-based Evacuation & the ENRICH Trial
Open to view video.
Open to view video. Gustavo Pradilla, MD, FAANS
CME Evaluation
10 Questions  |  2 attempts  |  7/10 points to pass
10 Questions  |  2 attempts  |  7/10 points to pass
8 Questions
1.50 AMA PRA Category 1 CreditsTM credits  |  Certificate available
1.50 AMA PRA Category 1 CreditsTM credits  |  Certificate available